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KMID : 1134820220510050412
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Journal of the Korean Society of Food Science and Nutrition
2022 Volume.51 No. 5 p.412 ~ p.418
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Enhancement of the Skin-Whitening and UV-Absorption Effects of Angelica gigas Extract by Lactiplantibacillus plantarum Fermentation
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Kim Jun-Hee
Hwang Youn-Seon
Kang Min-Ho
Yeom Suh-Hee
Park Jae-Hoon
Kim Jin-Woo
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Abstract
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This study was conducted to enhance the production of bioactive materials with skin-whitening and ultraviolet (UV)-A absorption activities using bioconverted Angelica gigas extract (BAE). The UV-B absorption and tyrosinase activity inhibition of the BAE using Lactiplantibacillus plantarum were 51.7±0.6% and 49.7±0.3%, respectively, which were 2.1 and 1.9 times higher than that of the hot-water extract. The cytotoxicity of BAE to B16F0 cells was analyzed using MTT assay, and no inhibition of cell growth was confirmed below 1 mg/mL. To study the mechanism of melanin synthesis for confirming the skin-whitening effects of BAE, the mRNA levels of tyrosinase related protein-1 (TRP-1) and protein-2 (TRP-2) were compared using a reverse transcription-polymerase chain reaction. The BAE reduced the expressions of TRP-1 and TRP-2, by 1.4 and 2.1 times, respectively, compared to HAE, proving that BAE is effective in inhibiting melanin synthesis. The bioconversion of BAE using L. plantarum showed enhanced UV-absorption and skin-whitening effects. Thus, BAE can be used as a multi-functional cosmetic ingredient with both UV-absorption and skin-whitening functions.
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KEYWORD
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Angelica gigas, Lactiplantibacillus plantarum, UV-absorption, skin-whitening, bioconversion
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